Develop standard notation for proteoforms

A major challenge in a new field like top-down proteomics, is to have a consistent and coherent method for describing the species being characterized.   The Consortium has launched this Sub-Committee to develop rules for writing a fully characterized proteoform.  This nomenclature is intended to be both machine and human readable, and to be sufficiently flexible to meet current and foreseeable needs.

The Committee will provide an unambiguous notation for writing an individual proteoform.  The notation needs have the following aspects:

  • Be Human readable. Suitable for display in written document or presentation.
  • Be Machine parsable.
  • Contain the complete amino acid sequence of the observed proteoform
  • Specify the location and type of each modification.

The Committee is working towards this goal and is expected to have a publication submitted in the Fall of 2017.

This project is open for public comment, and can be found at github.   Anyone interested in the project is encouraged to contact the committee chair, Richard LeDuc